P53: FROM FUNDAMENTAL BIOLOGY TO CLINICAL APPLICATIONS IN CANCER

p53: From Fundamental Biology to Clinical Applications in Cancer

p53 tumour suppressor gene is our major barrier against neoplastic transformation.It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system regulation, generation of reactive oxygen species, mitochondrial function, global regulation of gene expre

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Spectral Analyses and Structural Elucidation of Cyflumetofen

Cyflumetofen is a new type of acaricide with high Stools efficiency and low residue.In this work, the compound was characterized by infrared absorption (IR), ultraviolet absorption (UV) and mass spectrometry, as well as nuclear magnetic resonance spectroscopy (1H NMR, 13C NMR, DEPT, 1H-1H COSY, 1H-13C HSQC and 1H-13C HMBC).The characteristic absorp

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New algorithm for OHSS prevention

Abstract Ovarian hyperstimulation syndrome (OHSS) still remains a life-threatening complication of in vitro fertilization treatment (IVF), keeping patients and especially those, who previously experienced OHSS, from attempting infertility treatment and childbearing.The recent implementation of four new modalities: the GnRH antagonist protocol, GnRH

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Clustering by Partitioning around Medoids using Distance-Based Similarity Measures on Interval-Scaled Variables

It is reported in this paper, the results of a study of the partitioning around medoids (PAM) clustering algorithm applied to four datasets, both standardized and not, and of varying Boot Box sizes and numbers of clusters.The angular distance proximity measure in addition to the two more traditional proximity measures, namely the Euclidean distance

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